A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/70 (2006.01) A61K 47/30 (2006.01)
Patent
CA 2396686
The invention relates to a transdermal therapeutic system (TTS). In said system, the formation of oxidative degradation products is reduced by at least one active ingredient which is contained in the system and can be oxidised by hydroperoxides during storage of the TTS. Said system is characterised in that the maximum sum of the peroxide numbers (PON), exhibited by the constituent parts of the formulation which contain the active ingredient(s) prescribed by the recipe for the TTS is 20. The invention also relates to a method for producing a transdermal therapeutic system of this type.
La présente invention concerne un système thérapeutique transdermique (TTS) dans lequel la formation de produits de dégradation oxydatifs d'au moins un agent actif oxydable par des hydroperoxydes contenu dans ce système est réduite durant le stockage du TTS. Ledit système thérapeutique transdermique (TTS) est caractérisé en ce que la somme des nombres peroxydiques (POZ) présentant les parties données par la formulation du TTS, des constituants contenant le ou les agents actifs, ne dépasse pas 20. L'invention concerne également un procédé de fabrication d'un tel système thérapeutique transdermique.
Fetherstonhaugh & Co.
Lts Lohmann Therapie-Systeme Ag
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