Immortalized hepatocytes

Details Immortalized hepatocytes Immortalized hepatocytes

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2550452

This invention relates to virally-immortalized hepatocyte cell lines, which are derived from a normal primary human liver cell, have the ability to proliferate in a serum-free media, are nontumorigenic, and produce proteins. These cell lines can be used for toxicity testing of potential therapeutic drugs and chemical entities. The cell lines may also be used for the production of therapeutic plasma proteins.

L'invention concerne des lignées cellulaires d'hépatocytes immortalisés par virus, obtenues à partir d'une cellule hépatique humaine primaire normale, qui peuvent proliférer dans un milieu exempt de sérum, qui sont non oncogènes, et qui produisent des protéines. Ces lignées cellulaires peuvent servir dans des essais de toxicité auxquels sont soumis des médicaments thérapeutiques potentiels ainsi que des entités chimiques. Ces lignées cellulaires peuvent également servir dans la production de protéines plasmatiques thérapeutiques.

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