Preparation method of polymeric micelles composition...

Details Preparation method of polymeric micelles composition... Preparation method of polymeric micelles composition...

A - Human Necessities

61

K

A61K 9/127 (2006.01)

Patent

CA 2746983

Provided is a method for preparing a drug-containing polymeric micelle composition, which includes: dissolving a drug and an amphiphilic block copolymer into an organic solvent; and adding an aqueous solution to the resultant mixture in the organic solvent to form polymeric micelles, wherein the method requires no separate operation to remove the organic solvent prior to the formation of micelles. The method for preparing a drug-containing polymeric micelle composition is simple, reduces the processing time, and is amenable to mass production.

Cette invention concerne une méthode de préparation d'une composition de micelles polymères renfermant un médicament, ladite méthode consistant à dissoudre un médicament et un copolymère séquencé amphiphile dans un solvant organique, puis à ajouter une solution aqueuse au mélange résultant dans le solvant organique pour former des micelles polymères, la méthode ne nécessitant aucune opération distincte pour éliminer le solvant organique avant la formation des micelles. La méthode de préparation de la composition de micelles polymères contenant un médicament est simple, elle réduit la durée de traitement et convient pour une production en masse.

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