Thienopyridone derivatives as kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2528602

A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2- position by a carbonyl- or sulfonyl-linked pyrrolidin-1-yl or related moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

La présente invention a trait à une série de dérivés de thiéno[2,3-b]pyridin-6(7H)-one, substitués en position 2 par un pyrrolidin-1-yle à liaison carbonyle ou sulfonyle ou un groupe fonctionnel assimilé, qui sont des inhibiteurs de la protéine-kinase p38 associée aux membranes, et par conséquent utiles en médecine, par exemple dans le traitement et/ou la prévention de troubles immunitaires ou inflammatoires.

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