Non-covalent bioconjugates useful for magnetic resonance...

Details Non-covalent bioconjugates useful for magnetic resonance... Non-covalent bioconjugates useful for magnetic resonance...

A - Human Necessities

61

K

A61K 49/08 (2006.01) A61K 49/14 (2006.01)

Patent

CA 2322344

A composition having non-covalent carrier-hapten bioconjugates of the formula: HM ----- CM wherein HM is a hapten molecule whose molecular weight is generally, but not always, less than 1000 Daltons and is capable of performing specific functions; CM is a carrier molecule, whose molecular weight is generally, but not always, more than 1000 Daltons and is capable of transporting the hapten to a specific site; and the dashed line is a non- covalent bond between the carrier molecule and the hapten molecule. Preferably, the bioconjugates are formed from a paramagnetic metal complex and a carrier molecule such as methylated serum albumin, polyarginine, lysine-phenylalanine copolymer, polyacrylamide-co- diallyldimethylammonium, arginine-serine copolymer, and styrene-maleic acid copolymer.

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