Forming and modifying dielctrically-engineered microparticles

Details Forming and modifying dielctrically-engineered microparticles Forming and modifying dielctrically-engineered microparticles

G - Physics

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G01N 27/00 (2006.01) G01N 27/22 (2006.01) G01N 27/26 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/551 (2006.01) G01N 33/552 (2006.01) G01N 33/553 (2006.01)

Patent

CA 2470943

Engineered microparticles, libraries of microparticles, and methods relating thereto. The microparticles are distinguishable based on differences in dielectric response to an applied electric field. In different embodiments, the dielectric differences may be engineered through, but not limited to, dielectrically dispersive materials, surface charge, and/or fluorescence. Gangliosides may be incorporated with the microparticles to control aggregation. Vesicles including erythrocyte ghosts may be used as a basis for microparticles. The microparticles may utilize a biotin streptavidin system for surface functionalization

L'invention porte sur des microparticules artificielles, sur des bibliothèques de microparticules, et sur des procédés associés. Lesdites microparticules peuvent se distinguer en fonction des différences de la réponse diélectrique à un champ électrique appliqué. Dans différentes exécutions, les différences diélectriques peuvent être élaborées en utilisant des matériaux: diélectriquement dispersifs, à charge superficielle, et/ou fluorescents. On peut incorporer aux microparticules des gangliosides pour régler l'agrégation, et utiliser vésicules contenant des érythrocytes fantômes comme base des microparticules, lesquelles peuvent utiliser un système biotine-streptavidine pour la fonctionnalisation de surface.

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