A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61L 27/54 (2006.01) A61L 31/16 (2006.01)
Patent
CA 2464093
Disclosed is a device, such as a cardiovascular stent, autologous venous/arterial graft, prosthetic venous/arterial graft, vascular catheter, or vascular shunt, for stenting a blood vessel. The device has coated thereon, adsorbed thereto, impregnated therein, or covalently or ionically bonded thereto an amount of a protein tyrosine kinase inhibitor. The protein tyrosine kinase inhibitor proliferation of vascular smooth muscle cells in an area within a blood vessel immediately adjacent to and/or proximal to the device, while simultaneously not inhibiting the proliferation of vascular intimal cells. A corresponding method of using the device to stent blood vessels is also disclosed.
L'invention concerne un dispositif, tel qu'un stent cardiovasculaire, un greffon veineux/artériel autologue, un greffon veineux/artériel prothétique, un cathéter vasculaire ou un shunt vasculaire, destiné à la pose d'un stent dans un vaisseau sanguin. Une dose d'un inhibiteur de tyrosine kinase est appliquée par enduction, adsorption, imprégnation ou liaison covalente ou ionique sur ce dispositif. Cet inhibiteur de tyrosine kinase inhibe la prolifération des cellules musculaires lisses vasculaires dans une zone à l'intérieur d'un vaisseau sanguin se trouvant au voisinage immédiat et/ou à proximité du dispositif, mais, concomitamment, n'inhibe pas la prolifération des cellules intimales vasculaires. L'invention concerne également une méthode correspondante consistant à utiliser ce dispositif pour la pose d'un stent dans des vaisseaux sanguins.
Griffin Michael Orrin
Stoker Scott William
Wolff Matthew R.
Fetherstonhaugh & Co.
Griffin Michael Orrin
Stoker Scott William
Wisconsin Alumni Research Foundation
LandOfFree
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