Metapneumovirus strains and their use in vaccine...

Details Metapneumovirus strains and their use in vaccine... Metapneumovirus strains and their use in vaccine...

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C07H 21/02 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2600484

The invention relates to improved strains of mammalian negative strand RNA virus, metapneumo virus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention further relates to methods for propagating mammalian MPV in the absence of trypsin. The methods and compositions of the invention can be used for the preparation of vaccines against, e.g., MPV infections.

Cette invention concerne des souches améliorées d'un virus mammalien à ARN de polarité négative, le métapneumovirus (MPV), de la sous-famille pneumovirus de la famille des paramyxovirus. L'invention concerne en outre des méthodes de propagation du MPV mammalien en l'absence de trypsine. Les méthodes et les compositions de l'invention peuvent être utilisées pour la préparation de vaccins contre, p. ex., des infections à MPV.

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