Selective blocking of spontaneously-active dopamine neurones...

Details Selective blocking of spontaneously-active dopamine neurones... Selective blocking of spontaneously-active dopamine neurones...

A - Human Necessities

61

K

167/231

A61K 31/445 (2006.01)

Patent

CA 2014208

Psychoses in human beings is treated by administering an effective amount of the compound 5-chloro-1-(4- fluorophenyl)-3-(1-(2-(2-imidazolidinon-1-yl)ethyl)-4- piperidyl)-lH-indole, or a pharmaceutically acceptable salt thereof, to a patient in need thereof, the compound selectively blocks dopamine neurones in the ventral teqmental area of the brain, substantially without blocking the dopamine neurones in the substantia niqra pars compacta and, therefore, is free from the extrapyramidal side effects of common neuroleptics.

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