Statins for the treatment of ocular hypertension and glaucoma

A - Human Necessities – 61 – K

Patent

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A61K 31/00 (2006.01) A61K 9/00 (2006.01) A61K 31/366 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2560167

The use of HMG-CoA reductase inhibitors (e.g., statins) to treat glaucoma, control intraocular pressure, preserve the trabecular meshwork, protect against ocular neurodegeneration and/or protect against glaucomatous retinopathy is described. The preferred HMG-CoA reductase inhibitors, which are statins having an RI value of 0.2 to 0.7 (e.g., pravastatin), are administered via topical application to the affected eye(s) of the patient.

L'invention concerne l'utilisation d'inhibiteurs de la HMG-CoA réductase (par exemple de statines) pour traiter le glaucome, réguler la pression intraoculaire, préserver le trabéculum cornéoscléral, protéger contre une neurodégénérescence oculaire et/ou protéger contre une rétinopathie glaucomateuse. Les inhibiteurs de la HMG-CoA réductase préférés, qui sont des statines ayant une valeur de RI de 0,2 A 0,7 (par exemple la pravastatine), sont administrés par application topique sur l'oeil ou les yeux affect(é)s du patient.

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