Nonsedating a-2 agonist 1-(2,3-dimethyl-phenyl)-ethyl-1,...

A - Human Necessities – 61 – K

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A61K 31/4164 (2006.01) A61P 1/00 (2006.01) A61P 9/00 (2006.01) C07D 233/84 (2006.01)

Patent

CA 2537832

The present invention provides an .alpha.-2A/.alpha.-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provides a pharmaceutical composition that contains a pharmaceutical carrier and a therapeutically effective amount of an .alpha.- 2A/.alpha.-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof.

L'invention concerne un agoniste sélectif .alpha.-2A/.alpha.-1A qui comprend un composé représenté par la structure 1 ou un sel, un ester, un amide, un stéréo-isomère ou un mélange racémique pharmaceutiquement acceptables de ceux-ci. L'invention concerne de plus une composition pharmaceutique qui contient un excipient pharmaceutique et une quantité thérapeutiquement efficace d'un agoniste sélectif .alpha.-2A/.alpha.-1A comprenant un composé représenté par la structure 1 ou un sel, un ester, un amide, un stéréo-isomère ou un mélange racémique pharmaceutiquement acceptables de ceux-ci.

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