C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2497356
The present invention is directed to mutant forms of mGluR2 and mGluR3 that are shown to affect the binding of modulators of said receptors. The invention discloses polypeptides comprising the mutations, and nucleic acid sequences that encodes said polypeptides, and methods of using said polypeptides and nucleic acids sequences to identify, predict and evaluate specific, selective modulators whose association to mGlu2 or mGlur3 is effected by said mutations.
L'invention concerne des formes mutantes des mGluR2 et mGluR3 qui modifient la liaison des modulateurs de ces récepteurs. L'invention concerne également des polypeptides comprenant des mutations, et des séquences d'acides nucléiques codant ces polypeptides, ainsi que des procédés d'utilisation de ces polypeptides et des séquences d'acides nucléiques afin d'identifier, de prévoir et d'évaluer des modulateurs sélectifs spécifiques dont l'association à mGlu2 ou mGlur3 est mise en oeuvre par ces mutations.
Daggett Lorrie
Morales Sylvia
Schaffhauser Herve
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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