Thiepino [3,2-b] dihydropyridines and related compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01) A61P 13/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2403808

This invention provides novel thiepino[3,2-b]dihydropyridines of the formulae (I, II, V). These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

La présente invention concerne de nouvelles thiépino[3,2-b]dihydropyridines représentées par les formules (I, II, V) ci-après. Ces composés sont utilisés comme antagonistes des canaux calciques dotés d'une activité cardiovasculaire, antiasthmatique et antibronchoconstrictrice. L'invention concerne également des compositions pharmaceutiques et des méthodes permettant de prévenir et de traiter des affections telles que l'hypersensibilité, l'allergie, l'asthme, le bronchospasme, la dysménorrhée, le spasme de l'oesophage, le glaucome, l'accouchement prématuré, les infections des voies urinaires, les troubles de la motilité gastro-intestinale ou les troubles cardiovasculaires.

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