Production of mutant strain of aspergillus fumigatus and...

Details Production of mutant strain of aspergillus fumigatus and... Production of mutant strain of aspergillus fumigatus and...

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 45/00 (2006.01) A61P 31/10 (2006.01) C12N 1/15 (2006.01) C12N 15/31 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2472695

This application relates to the production and characterization of a mutant strain of Aspergillus fumigates. The application also relates to a method for inhibiting siderophore biosynthesis in Aspergillus fumigates and an assay for identifying drug candidates or other agents having potential inhibitory activity. The method may comprise, for example, the step of inhibiting an enzyme catalyzing siderophore biosynthesis, such as L-ornithine N5-oxygenase. In one embodiment the siderophore is a hydroxamate siderophore, such as N'N"N"'-triacetylfusarinine C (TAF) or ferricrocin. A method of preventing or treating fungal infections in a patient is also described comprising administering to the patient an agent suitable for inhibiting fungal secretion of siderophores. The method is particularly useful for immunocompromised patients susceptible to fungal infections caused by Aspergillus fumigates, such as pulmonary aspergillosis.

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