System for producing dimeric proteins based on the...

Details System for producing dimeric proteins based on the... System for producing dimeric proteins based on the...

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2534299

The system comprises a DNA construction comprising: a) a first sequence of nucleic acid containing the sequence of nucleotides coding for a product of interest; b) a second sequence of nucleic acid containing the sequence of nucleotides coding for a dimerization domain and c) a third sequence of nucleic acid containing the sequence of nucleotides coding for a-hemolysin (HlyA) of Escherichia coli or for a fragment of said protein comprising the signal recognizing the secretion mechanism of the transport system of hemolysin (Hly) of E. Coli. The method can be applied in the production of recombinant dimeric proteins.

L'invention concerne un système présentant une construction d'ADN comprenant a) une première séquence d'acide nucléique contenant une séquence nucléotidique codant pour un produit d'intérêt; b) une deuxième séquence d'acide nucléique contenant une séquence nucléotidique codant pour un domaine de dimérisation; et c) une troisième séquence d'acide nucléique contenant une séquence nucléotidique codant pour la a-hémolysine (HlyA) d'Escherichia coli ou pour un fragment de ladite protéine comprenant le signal de reconnaissance du mécanisme de sécrétion du système de transport de l'hémolysine (Hly) d'E. Coli. L'invention s'utilise dans la production de protéines de recombinaison dimériques.

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