C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01)
Patent
CA 2594109
The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
La présente invention porte, d'une manière générale, sur un processus permettant de préparer directement des sels pharmaceutiquement acceptables enrichis par rapport à des sels rotamériques choisis d'un composé basique par un choix approprié d'un acide et d'un milieu solvant. Le processus de cette invention s'avère particulièrement utile pour préparer des rotamères spécifiques de sels pharmaceutiquement utiles selon la prépondérance souhaitée d'un rotamère.
D'sa Bosco
Klopfer Kevin
Lee Hong-Chang
Leong William
Liang Feng
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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