C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2539434
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying the subject having increased or decreased sensitivity to warfarin.
La présente invention concerne une technique d'identification d'une personne possédant une sensibilité moindre ou accrue à la warfarine, qui consiste à détecter chez cette personne la présence d'un polymorphisme nucléotidique simple dans le gène VKOR, ce polymorphisme nucléotidique simple étant corrélé à une moindre sensibilité ou à une sensibilité accrue à la warfarine, ce qui permet d'identifier la personne dont la sensibilité à la warfarine est moindre ou accrue.
Li Tao
Stafford Darrel W.
Sim & Mcburney
University Of North Carolina At Chapel Hill
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