Polypeptides from mycobacterium paratuberculosis

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/04 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/35 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2106962

The invention relates to a polypeptide containing in its polypeptidic chain: the amino acid sequence of 101 amino acids of Figure 8, or a fragment of this sequence, this fragment being such that it is liable to be recognized by antibodies also recognizing the above said sequence of 101 amino acids, but it is not recognized by antibodies respectively raised against M. bovis, M. avium. M, phlei and M. tuberculosis, and possibly against M. leprae, M. intracellulare, M. scrofulaceum, M. fortuitum, M. gordonae and M. smegmalis; it is liable to generate antibodies which also recognize the above said sequence of 101 amino acids but which do not recognize M: bovis, M. avium, M. phlei and M. tuberculosis, and possibly M. leprae, M. intracellulare, M. scrofulaceum, M. fortuitum, M, gordonae and M. smegmatis; it reacts with the majority of sera from cattle suffering from Johne's disease; or the polypeptidic sequences resulting from the modification by substitution and/or by addition and/or by deletion of one or several amino acids in so far as this modification does not alter the above-mentioned properties.

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