Phospholipid nucleosides

Details Phospholipid nucleosides Phospholipid nucleosides

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/10 (2006.01) A61K 31/675 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2004695

Phospholipids of 2'-deoxy-2',2'-difluoro- nucleosides, where the phosphorus-containing moiety is linked to the 5'-oxygen of the nucleoside, are useful antineoplastic agents. A process for improved phosphorylation of the nucleosides uses a large excess of POCl3.

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