C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/54 (2006.01) A61K 31/445 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2359983
A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted azetidine, pyrrolidine or piperidine ring are selective antagonists of the human 5-HT2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and depression.
L'invention concerne une classe de dérivés de phénylsulphonyle dans lesquels le groupe sulphonyle est également lié à un noyau azétidine pyrrolidine ou pipéridine à substitution N-arylalkyle. Ces composants sont des antagonistes sélectifs du récepteur 5-HT¿2A? humain et sont par conséquent utiles en tant qu'agents pharmaceutiques, en particulier pour le traitement et/ou la prévention de pathologies du système nerveux central, notamment la schizophrénie et la dépression.
Blurton Peter
Burkamp Frank
Cheng Susan Koon-Fung
Fletcher Stephen Robert
Macleod Angus Murray
Merck Sharp And Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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