Combinations of anthelmintically active agents

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01) A61K 31/33 (2006.01) A61K 31/35 (2006.01) A61K 31/365 (2006.01) A61K 31/495 (2006.01) A01N 43/90 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2096346

Pharmaceutical compositions comprising a compound of formula (I), in which R is optionnally substituted phenyl; C3-8 cycloalkyl; C5-8 cylcoalkenyl; C1-8 alkyl which may be straight or branched; C2-8 alkenyl which may be straight or branched; 5- or 6- membered heterocyclyl; or optionally substituted phenyl C1- 4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is a bond, -CH2-, or oxygen; and at least one other anthelmintically active compound which is an avermectin or milbemycin, are useful in the treatment of helminthiasis.

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