Polymers with controlled physical state and bioerodibility

Details Polymers with controlled physical state and bioerodibility Polymers with controlled physical state and bioerodibility

C - Chemistry, Metallurgy

08

G

C08G 65/28 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61L 27/00 (2006.01) A61L 27/18 (2006.01) C08G 63/664 (2006.01) C08G 65/00 (2006.01) C08G 65/34 (2006.01)

Patent

CA 2242631

The present invention relates to polymers useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents. The polymers are prepared in such a manner that the rate and degree to which they are hydrolyzed can be controlled without addition of exogeneous acid. This discovery resides in the incorporation of esters of short-chain .alpha.-hydroxy acids such as esters of glycolic acid, lactic acid or glycolic-co-lactic acid copolymer into the polymer chain and variation of the amount of these esters relative to the polymer as a whole.

La présente invention concerne des polymères convenant comme implants ou excipients orthopédiques et permettant la libération prolongée d'agents pharmaceutiques, cosmétiques et agricoles. Ces polymères sont préparés de façon qu'il est possible de réguler leur vitesse et leur degré d'hydrolyse sans addition d'acide exogène. La caractéristique principale de l'invention est l'incorporation, dans la chaîne du polymère, d'esters d'acides alpha -hydroxy à chaînes courtes tels que les copolymères d'esters d'acide glycolique, d'acide lactique ou d'acide glycolique-co-lactique, et la variation de la quantité de ces esters par rapport au polymère dans son ensemble.

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