Mcbi analogs of cc-1065 and the duocarmycins

Details Mcbi analogs of cc-1065 and the duocarmycins Mcbi analogs of cc-1065 and the duocarmycins

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4025 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01) C07D 209/60 (2006.01) C07D 209/70 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 519/00 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2246783

MCBI (7-methoxy-1,2,9,9a-tetra-hydrocyclopropa[c]benz[e]indol-4-one) is employable as a DNA alkylating agent and can be incorporated into analogs of CC-1065 and the duocarmycins for constructing regioselective DNA alkylating agents.

La MCBI (7-méthoxy-1,2,9a-tétra-hydrocyclopropa[c]benz[e]indol-4-one) peut être utilisée comme agent alkylant de l'ADN et elle peut être incorporée dans des analogues de CC-1065 et des duocarmycines pour réaliser des agents d'alkylation régiosélectifs de l'ADN.

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