C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/88 (2006.01) A61K 31/36 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 263/56 (2006.01)
Patent
CA 2352592
A range of quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA- damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed comprise certain quinazolinone compounds having the general structural formula II Image or pharmaceutically acceptable salt thereof, characterised in that X' represents hydroxyl, alkyl, alkoxy or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g. benzyl) group, and Y' represents hydrogen, alkyl or an optionally substituted aryl (e. g. phenyl) or aralkyl (e. g. benzyl) group.
Calvert Alan Hilary
Curtin Nicola Jane
Golding Bernard Thomas
Griffin Roger John
Newell David Richard
Borden Ladner Gervais Llp
Newcastle University Ventures Limited
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