Inhibitors of prenyl-protein transferase

Details Inhibitors of prenyl-protein transferase Inhibitors of prenyl-protein transferase

A - Human Necessities

61

K

A61K 31/535 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 233/54 (2006.01) C07D 233/66 (2006.01) C07D 233/90 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 419/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2306746

The present invention is directed to compounds which inhibit a prenyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting a prenyl-protein transferase and the prenylation of the oncogene protein Ras.

L'invention concerne des composés inhibant une transférase de prényl-protéine (FTase) et la farnésylation de la protéine Ras oncogène. L'invention concerne en outre des compositions chimiothérapiques contenant les composés précités, ainsi que des procédés d'inhibition d'une transférase de prényl-protéine et la prénylation de la protéine Ras oncogène.

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