Separation of the enantiomers of amlodipine via their...

Details Separation of the enantiomers of amlodipine via their... Separation of the enantiomers of amlodipine via their...

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01)

Patent

CA 2186263

A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO) for the precipitation of, respectively, a DMSO solvate of an L-tartrate salt of R-(+)-amlodipine, or a DMSO solvate of a D-tartrate salt of S-(-)- amlodipine.

Procédé de séparation d'isomères R-(+)- et S-(-)- d'amlodipine (I) à partir de mélanges de ces isomères, consistant à faire réagir le mélange d'isomères soit avec de l'acide L-tartrique, soit avec de l'acide D-tartrique, dans un solvant organique contenant suffisamment de sulfoxyde diméthylique (DMSO) pour qu'il y ait précipitation respectivement d'un solvate de DMSO d'un sel de L-tartrate de R-(+)-amlodipine, ou d'un solvate de DMSO d'un sel de D-tartrate de S-(-)-amlodipine.

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