Quinazoline derivatives and their preparation

Details Quinazoline derivatives and their preparation Quinazoline derivatives and their preparation

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/96 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2053475

ABSTRACT Compounds of the formula: Image in which R1 and R2 are each hydrogen, halogen, nitro, amino, protected amino, hydroxyamino, lower alkoxy, lower alkyl, hydroxy, sulfamoyl, carboxy, protected carboxy, carbamoyl, mercapto, lower alkylthio or imidazolyl, R3 is aryl which may have suitable substituent(s), A is lower alkylene, and the formula: Image is N-containing heterocyclic group, or pharmaceutically acceptable salts thereof. These compounds display effects on the periperal or central nervous system, in particular the peripheral nervous system. These compounds are also useful as dopamine receptor agonists. They are particularly useful for treating hypertension, cardiovascular disorders (e.g. angina pectoris, myocardial infarction, etc.), Parkinsonism and the like. The preparation of these compounds is also disclosed as well as pharmaceutical compositions containing them and medical treatments using them.

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