A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A01N 43/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 51/00 (2006.01) C07B 61/00 (2006.01) C07C 215/60 (2006.01) C07C 217/08 (2006.01) C07C 323/62 (2006.01) C07D 211/42 (2006.01) C07D 211/56 (2006.01) C07D 213/74 (2006.01) C07D 213/80 (2006.01) C07D 263/32 (2006.01) C07D 263/34 (2006.01) C07D 265/32 (2006.01) C07D 277/24 (2006.01) C07D 277/28 (2006.01) C07D 277/34 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/06 (
Patent
CA 2319650
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi- binding compound so constructed demonstrates increased modulation or disruption of the biological processes/functions of the cell. Also disclosed is a method for identifying such novel multi-binding compounds which bind cellular receptors and a method for generating a mixture of such novel multi- binding compounds.
Cette invention a trait à de nouveaux composés (agents) capables de multiples fixations et se fixant à des récepteurs cellulaires. Ces composés comprennent plusieurs ligands, pouvant, chacun, se fixer à ces récepteurs cellulaires et, partant, moduler leurs processus/fonctions biologiques. Chaque ligand est rattaché, de manière covalente, à une ou à des séquences de liaison pouvant être identiques ou différentes afin de convenir au récepteur à multiples fixations. La séquence de liaison est choisie de manière que le composé à multiples fixations ainsi construit témoigne d'une augmentation de sa capacité à moduler ou à dérégler des processus/fonctions biologiques de la cellule. L'invention concerne également une technique d'identification de ces nouveaux composés à multiples fixations se fixant à des récepteurs cellulaires ainsi qu'une technique de mise au point d'un mélange de ces nouveaux composés.
Griffin John H.
Mammen Mathai
Marquess Daniel
Advanced Medicine Inc.
Theravance Inc.
Torys Llp
LandOfFree
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