Substituted hydroxyethylamines

Details Substituted hydroxyethylamines Substituted hydroxyethylamines

C - Chemistry, Metallurgy

07

C

C07C 215/18 (2006.01) C07C 215/10 (2006.01) C07C 217/58 (2006.01) C07C 217/64 (2006.01) C07C 233/36 (2006.01) C07C 233/40 (2006.01) C07C 233/78 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 271/28 (2006.01) C07C 309/74 (2006.01) C07C 311/09 (2006.01) C07C 323/38 (2006.01) C07C 323/42 (2006.01) C07D 263/30 (2006.01) C07D 263/32 (2006.01) C07D 263/48 (2006.01) C07D 303/36 (2006.01)

Patent

CA 2469622

Disclosed are compounds of the formula (I) and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and RC are defined herein. These compounds interact with and inhibit the activity of the enzyme beta- secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.

L'invention concerne des composés de la formule (I) et les sels pharmaceutiquement acceptables desdits composés. Dans ladite formule, les variables G, L, A, W, E, R2, R3, R4, R5, R<sb>N</sb> et R<sb>C</sb> sont telles que définies dans le mémorandum descriptif. Ces composés interagissent avec l'enzyme bêta-sécrétase et inhibent son activité. Les composés de l'invention sont donc utiles pour le traitement de la maladie d'Alzheimer ou d'autres maladies similaires. L'invention concerne en outre des compositions pharmaceutiques et des méthodes de traitement de ces maladies.

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