C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 8/64 (2006.01) A61K 38/17 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) G01N 33/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2299560
The invention concerns a novel human polypeptide defensin, homologous of HNP-4, its genomic DNA and DNAc, vectors, cells transformed by said vectors, the use of said polypeptide as antibiotic, cytotoxic, repairing and endocrine regulating agent or as pesticide as well as cosmetic or pharmaceutical compositions for treating microbial infections, in particular bacterial, fungal, and viral, or parasitic, cancers, inflammation and immunodeficiency. The invention also concerns diagnostic methods and kits for determining a microbial or parasitic infection and an inflammation, or for detecting predisposition to immunodeficiency or cancerous diseases.
La présente invention concerne une nouvelle défensine polypeptidique humaine Def-X, homologue de l'HNP-4, son ADN génomique et ADNc, des vecteurs, des cellules transformées par lesdits vecteurs, l'utilisation dudit polypeptide comme agent antibiotique, cytotoxique, de réparation et de régulation endocrine ou comme pesticide ainsi que des compositions cosmétiques ou pharmaceutiques pour le traitement des infections microbiennes, notamment bactériennes, fongiques, et virales, ou parasitaires, de cancers, de l'inflammation et de déficit immunitaire. L'invention concerne également des méthodes et des kits de diagnostic pour la détermination d'une infection microbienne ou parasitaire et d'une inflammation, ou pour le dépistage de prédisposition à des déficiences immunitaires ou des maladies cancéreuses.
Bougueleret Lydie
Chumakov Ilya
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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