C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/26 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2517720
Novel pyrazine compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.beta. signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
L'invention concerne des composés nouveaux de pyrazine, leurs dérivés, des intermédiaires utiles pour les préparer, des compositions pharmaceutiques qui les contiennent et leur utilisation en médecine. Les composés décrits constituent des inhibiteurs puissants de la voie de signalisation du facteur de croissance transformant-.beta. (<= TGF-.beta. >=). Ils sont utiles pour traiter différentsétats pathologiques associés au TGF, y compris le cancer et les maladies fibreuses, par exemple.
Pfizer Products Inc.
Sim & Mcburney
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