Quinoline and isoquinoline derivatives as phosphodiesterase...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/04 (2006.01) A61K 31/47 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2644850

The present invention is directed to certain quinoline and isoquinoline compounds that are PDElO inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The invention is also directed to methods of treating diseases mediated by PDElO enzyme, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

La présente invention concerne certains dérivés de quinoline et d'isoquinoline qui sont des inhibiteurs de PDE10, des compositions pharmaceutiques contenant de tels composés et des procédés de synthèse de tels composés. La présente invention concerne également des méthodes de traitement de maladies faisant intervenir l'enzyme PDE10, par exemple l'obésité, le diabète non insulinodépendant, la schizophrénie, les troubles bipolaires, les troubles obsessionnels compulsifs, etc.

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