C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/59 (2006.01) C07K 16/26 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2320391
The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid residues that is at least 80 % identical in amino acid sequence to residues 1 through 106 of SEQ ID NO:2. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
L'invention concerne des molécules de polynucléotides et de polypeptides pour l'élaboration d'un nouveau membre, zsig51, de la famille des polypeptides à noeud de cystine. Les polypeptides considérés renferment une séquence de résidus d'acides aminés identique au moins à 80 % en termes de séquence d'acides aminés aux résidus 1 à 106 de la séquence numérotée SEQ ID NO:2. L'invention concerne en outre des procédés thérapeutiques et diagnostiques utilisant ces polynucléotides, ces polypeptides, et des antagonistes vis-à-vis desdits polypeptides.
Lok Si
Sheppard Paul O.
Smart & Biggar
Zymogenetics Inc.
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