Oral solid dosage forms containing a low dose of estradiol

Details Oral solid dosage forms containing a low dose of estradiol Oral solid dosage forms containing a low dose of estradiol

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2585095

The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.

La présente invention concerne des formes posologiques orales solides contenant une très faible dose d'oestradiol. Ces formes posologiques sont préparées de manière à éviter une dégradation de l'oestradiol et à réduire le contenu de polyvinylpyrrolidone, tandis qu'elles parviennent toujours à une dissolution similaire rapide de l'oestradiol. Lesdites formes posologiques sont utilisées dans la prévention ou le traitement d'un trouble physique chez la femme, provoqué par des niveaux endogènes insuffisants d'oestradiol.

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