C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/74 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61P 9/00 (2006.01) A61P 19/00 (2006.01) C07K 7/06 (2006.01)
Patent
CA 2491135
Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp- Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
L'invention porte sur des dimres d~rivant de la thrombine comprenant deux polypeptides pr~sentant la s~quence d'acide amin~ SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, ou un fragment C-terminal tronqu~ du polypeptide pr~sentant au moins six acides amin~s. Z~ro, un, deux, ou trois acides amin~s du polypeptide, ou du fragment de polypeptide, diffrent de par leur position correspondante dans SEQ ID NO. 2. L'invention porte ~galement sur des m~thodes de traitement de sujets n~cessitant un traitement par un agoniste du r~cepteur de la thrombine consistant ~ administrer une dose efficace du d~riv~ de la thrombine d~crit ci-dessus.
Borden Ladner Gervais Llp
The Board Of Regents The University Of Texas System
LandOfFree
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