Enzymatic neutralization of heparin

Details Enzymatic neutralization of heparin Enzymatic neutralization of heparin

C - Chemistry, Metallurgy

12

N

C12N 9/88 (2006.01) A61K 38/51 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2083162

A heparinase formulation derived from F. heparinum which meets all requirements for a clinical reagent that can eliminate heparin interference of normal blood function has been developed. The heparinase, derived from F. heparinum, is free of a component that inhibits coagulation. It is stable under normal manufacturing, shipping and clinical storage conditions for a least one year. The heparinase is useful in vitro to eliminate the interference in hematological assays due to the presence of heparin. The heparinase is also useful for the in vivo neutralization of heparin during surgical procedures. Advantages of this preparation are that it achieves neutralization faster and more completely than previously available compositions and is stable for long periods of time.

Formulation d'héparine dérivée de F. heparinum satisfaisant à tous les critères d'un réactif clinique capable d'éliminer l'interférence de l'héparine dans la fonction sanguine normale. L'héparinase, dérivée de F. heparinum, ne compte aucun composé inhibant la coagulation. En conditions normales de fabrication, d'expédition et de conservation en clinique, elle demeure stable pour au moins un an. L'héparinase est utile in vitro pour éliminer l'interférence due à la présence d'héparine dans les dosages hématologiques. Elle est également utile pour la neutralisation de l'héparine in vivo durant les interventions chirurgicales. Les avantages de cette préparation sont de permettre une neutralisation plus rapide et plus complète que les compositions auparavant disponibles, et de demeurer stable longtemps.

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