Screening for non-genotoxic carcinogens

Details Screening for non-genotoxic carcinogens Screening for non-genotoxic carcinogens

A - Human Necessities

01

K

A01K 67/027 (2006.01)

Patent

CA 2717705

The invention relates to a method for screening for the effects of non- genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPAR.alpha., and in which the endogenous equivalent genes have been rendered inoperable.

L'invention porte sur un procédé pour le criblage des effets de carcinogènes non génotoxiques dans un modèle animal. L'invention porte également sur des modèles animaux qui sont appropriés pour une utilisation dans un tel procédé, et sur des lignées cellulaires issues de ces animaux pour des objectifs de criblage in vitro. Plus spécifiquement, l'invention porte sur un animal rongeur transgénique qui a été humanisé pour les facteurs de transcription nucléaires CAR, PRX et PPARa, et dans lequel les gènes endogènes équivalents ont été rendus inopérants.

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