Process for the preparation of (-)-a-difluoromethylornithine...

Details Process for the preparation of (-)-a-difluoromethylornithine... Process for the preparation of (-)-a-difluoromethylornithine...

C - Chemistry, Metallurgy

07

C

C07C 227/34 (2006.01) C07B 57/00 (2006.01) C07C 229/26 (2006.01)

Patent

CA 2345112

According to the invention, (+/-)-.alpha.-(difluoromethyl)ornithine is cleaved into its isomers by means of (-)-O, O'-di-p -toluyol -L-tartaric acid. (+/-) - .alpha.- (difluoromethyl)ornithine -monohydroch loride monohydrate and notably its (-)-isomer are inhibitors of ornithine decarboxylase and thus have numerous pharmacological actions.

De la (+/-)-.alpha.-(difluorométhyl)ornithine est clivée en ses isomères à l'aide d'acide (-)-O,O'-di-p-toluoyl-L-tartrique. Le monohydrate de monohydrochlorure de (+/-)-.alpha.-(difluorométhyl)ornithine et en particulier le (-)-isomère sont des inhibiteurs de l'ornithinedécarboxylase et possèdent ainsi de nombreuses actions pharmacologiques.

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