A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/529 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2664165
The present invention is concerned with the finding that the macrocyclic quinazoline derivative 4,6-ethanediylidenepyrimido[4,5-b][6,1,12]benzoxadiazacyclo-pentadecine, 17-bromo-8,9,10,11,12,13, 14,19-octahydro-20-methoxy-13-methyl-, described as compound 22 in PCT publication WO2004/105765, is useful in the manufacture of a medicament for the treatment or prevention of bone cancers and methods for killing bone cancer cells, including osteosarcomas, chondrosarcomas, myeloma bone disease and osteolytic bone metastases from other primary sites. It accordingly provides methods for treating, preventing, delaying or mitigating bone cancer, or for preventing and treating of bone loss associated with cancer metastases.
La présente invention concerne l'observation selon laquelle un dérivé macrocyclique de la quinazoline, le 4,6-éthanediylidène pyrimido[4,5-b][6,1,12]benzoxadiazacyclo-pentadécine, 17-bromo-8,9,10,11,12,13, 14,19-octahydro-20-méthoxy-13-méthyl-, décrit en tant que composé 22 dans la publication du PCT WO2004/105765, est utilisable pour la fabrication d'un médicament destiné au traitement ou à la prévention des cancers des os, ainsi que des procédés de destruction des cellules cancéreuses des os, telles que les ostéosarcomes, les chondrosarcomes, la tumeur osseuse ou myélome et les métastases osseuses ostéolytiques provenant d'autres sites primaires. En conséquence, l'invention concerne des procédés de traitement, de prévention, de ralentissement ou de soulagement du cancer des os ou des procédés de prévention et de traitement de la perte osseuse associée aux métastases cancéreuses.
Freyne Eddy Jean Edgard
Janicot Michel Marie Francois
Meert Theo Frans
Perera Timothy Pietro Suren
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Nv
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