Cell permeable peptides for inhibition of inflammatory...

A - Human Necessities – 61 – K

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Details

A61K 38/17 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2391943

The present invention relates to the delivery of biologically active molecules, such as peptides, into the interior of cells by administering to the cells a complex comprising the molecule linked to an importation competent signal peptide. Such delivery can be utilized, for example, to treat and/or prevent inflammatory conditions, e.g., but not limited to, systemic inflammatory reactions such as endotoxic shock, localized inflammatory reactions such as inflammatory skin diseases and conditions, and inflammatory diseases such as autoimmune diseases.

La présente invention concerne l'administration de molécules biologiquement actives, telles que des peptides, à l'intérieur de cellules, consistant à administrer un complexe renfermant la molécule liée à un peptide signal compétent d'importation aux cellules. L'administration peut être utilisée pour traiter et/ou prévenir des états inflammatoires, par exemple, notamment pour traiter et/ou prévenir des réactions inflammatoires systémiques telles que des chocs endotoxiques, des réactions inflammatoires localisées telles que des maladies et des états inflammatoires de la peau et des maladies inflammatoires telles que des maladies auto-immunes.

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