Enteric coated particles containing an active ingredient

A - Human Necessities – 61 – K

Patent

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A61K 9/26 (2006.01)

Patent

CA 2654663

Enterically coated particles and chewable tablets made therefrom are disclosed. The enterically coated particles are comprised of a core containing an active ingredient, a first coating layer comprised of polymeric composition having a Tg less than about 40°C that substantially covers the core; and a second coating layer, which substantially covers the first coating layer, comprised of a high temperature film forming polymer. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient.

L'invention concerne des particules à enrobage entérique et des comprimés à croquer faits à partir de celles-ci. Les particules à enrobage entérique sont composées d'un noyau contenant un ingrédient actif, d'une première couche de revêtement composée d'une composition polymère ayant une Tg inférieure à environ 40 °C qui recouvre sensiblement le noyau ; et d'une seconde couche de revêtement, qui recouvre sensiblement la première couche de revêtement, composée d'un polymère formant un film à température élevée. Les particules peuvent être produites sous forme de comprimés, par exemple sous forme de comprimés à croquer, qui procurent la libération immédiate de l'ingrédient actif.

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