A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7036 (2006.01) A61K 9/00 (2006.01) A61K 31/4709 (2006.01) A61L 27/02 (2006.01) A61L 27/14 (2006.01) A61L 27/28 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2396146
The invention concerns the manufacture of an antibiotic coating of elements with interconnecting microcavities, elements thus coated as well as their use. In a preferred embodiment, a homogenous solution of gentamicin pentakis dodecyl sulfate, of gentamicin tetrakis dodecyl sulfate, of gentamicin pentakis dodecyl sulfonate or of gentamicin tetrakis dodecyl sulfonate which contains methanol and/or ethanol and/or N,N-demethyl formamide and/or dimethyl sulfoxide as a solvent is introduced into the microcavities of non-metallic elements with interconnecting microcavities which are built up of collagen or gelatine or polyesters or tricalcium phosphate or hydroxyl apatite through dipping, spraying and dripping, and following evaporation or vaporization of the organic solvent, a layer of gentamicin pentakis dodecyl sulfate, gentamicin tetrakis dodecyl sulfate, gentamicin pentakis dodecyl sulfonate or gentamicin tetrakis dodecyl sulfonate is formed on the surface of the microcavities.
Kuhn Klaus-Dieter
Schnabelrauch Matthias
Vogt Sebastian
Heraeus Kulzer Gmbh & Co. Kg
Macrae & Co.
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