Therapeutic pore-forming peptides

Details Therapeutic pore-forming peptides Therapeutic pore-forming peptides

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 39/002 (2006.01) C07K 14/44 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2411244

A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group. These agents are useful in treating cancer, especially prostate cancer.

L'invention porte sur une classe d'agents procytotoxiques se caractérisant par leur capacité à tuer de manière spécifique une cellule cible. Selon une variante de cette invention, une protéine formant des pores possède au moins un reste de lysine modifié par une liaison peptidique à un reste d'amino acide, via le groupe amino epsilon. Ces agents sont utiles dans le traitement du cancer, notamment le cancer de la prostate.

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