C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/505 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2332932
Compounds of formula (I) in which R1, R2 and R3 are hydrogen, 1-4C-alkyl or halogen, R4, R5, R6 and R9 are hydrogen or 1-4C-alkyl, R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy or halogen, A is 1-7C-alkylene, 2-7C-alkenylene, 3-7C- cycloalkylene or phenylene, G is hydrogen, hydroxyl, 1-7C-alkyl, 1-4C-alkyl which is completely or mainly substituted by fluorine, 2-7C-alkenyl, 3-7C- cycloalkyl, a mono- or di-1-4C-alkylcarbamoyl or -thiocarbamoyl radical, an N- 1-4C-alkyl-N'-cyanoamidino radical, a 1-N-1-4C-alkylamino-2-nitroethylene radical, an N-2-propynyl-N'-cyanoamidino radical, an aminosulfonylamidino radical, the radical -N(R10)R11, the part of the compound of formula (I) bonded to A (including X and via X), the glucopyranoside radical or a cyclic system or bicyclic system which is unsubstituted or substituted by R12 and R13 and which is selected from the group consisting of benzene, napththalene, furan, thiophene, pyrrole, oxazole, oxazoline, oxazolidinone, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tetrazole, thiadiazole, thiadiazole 1-oxide, oxadiazole, pyridine, pyridine N- oxide, pyrimidine, halopyrimidine, piperidine, triazine, pyridone, benzimidazole, imidazopyridine, benzothiazole, benzoxazole, quinoline and imidazopyridazine, X is O (oxygen), N-1-4C-alkyl, NH or S, Y is O (oxygen), N- 1-4C-alkyl, NH, S 1,4-piperazinylene or 1,4-piperidinylene, Z is O (oxygen), N- 1-4C-alkyl, NH or S or CO, m is a number from 1 to 7, n is a number from 0 to 4, t is the number 0, 1 or 2 and u is the number 0 or 1, and their salts, are suitable for the control of Helicobacter bacteria.
L'invention concerne des composés de formule (I), dans laquelle R1, R2 et R3 représentent hydrogène, alkyle C1-4 ou halogène, R4, R5, R6 et R9 représentent hydrogène ou alkyle C1-4, R7 et R8 représentent hydrogène, alkyle C1-4, alcoxy C1-4 ou halogène, A représente alkylène C1-7, alcénylène C2-7, cycloalkylène C3-7 ou phénylène, G représente hydrogène, hydroxyle, alkyle C1-7, alkyle C1-4 qui est intégralement ou principalement substitué par fluor, alcényle C2-7, cycloalkyle C3-7, un radical mono ou di-alkylcarbamoyle C1-4 ou thiocarbamoyle, un radicale N-alkyle C1-4-N'-cyanoamidino, un radical 1-N-alkylamino C1-4-2-nitroéthylène, un radical N-2-propynyl-N'-cyanoamidino, un radical aminosulfonylamidino, le radical N(R10)R11, la partie du composé de ladite formule (I) étant lié à A (X inclus et par l'intermédiaire de X), le radical glucopyranoside ou un système cyclique ou bicyclique substitué ou non par R12 et R13, et qui est choisi dans le groupe formé de benzène, naphtalène, furane, thiophène, pyrrole, oxazole, oxazoline, oxazolidinone, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tétrazole, thiadiazole, 1-oxyde de thiadazole, oxadiazole, pyridine, N-oxyde de pyridine, pyrimidine, halopyrimidine, pipéridine, triazine, pyridone, benzimidazole, imidazopyridine, benzothiazole, benzoxazole, quinoléine et imidapyridazine, X représente O (oxygène), N-alkyle C1-4, NH ou S, Y représente O (oxygène), N-alkyle C1-4, NH, 1,4-pipérazinylène ou 1,4-pipéridinylène, Z représente O (oxygène), N-alkyle C1-4, NH ou S ou CO, m vaut un chiffre de 1 à 7, n vaut un chiffre de 0 à 4, t vaut 0, 1 ou 2 et u vaut 0 ou 1. L'invention porte aussi sur des sels desdits composés. Lesdits composés et sels sont utiles dans la lutte contre les bactéries Helicobacter.
Grundler Gerhard
Zimmermann Peter
Altana Pharma Ag
Byk Gulden Lomberg Chemische Fabrik Gmbh
Gowling Lafleur Henderson Llp
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