Model for gonococcal infection

Details Model for gonococcal infection Model for gonococcal infection

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A01K 67/027 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/095 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/12 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160155

An animal having a disseminated infection with an organism requiring human factor Clq binding for pathogenicity. The animal, preferably a rat, is produced by administration of the organism coated with human factor Clq. The organism is, in particular, Neisseria gonorrhoeae. The rat infected with Clq-coated Neisseria gonorrhoeae provides a model for the disease state. This rat model allows the development and testing of possible prophylactic and therapeutic agents for the disease and is particularly useful as a model for the advanced stages of gonococcal infection in females. Prophylactic or therapeutic compositions including antibodies or Neisseria gonorrhoeae peptides with binding specificity for human factor Clq are described. A Clq synthetic analog having binding specificity for N. gonorrhoeae and without binding specificity for eukaryotic cells is described as being useful to treat gonoccocal infection.

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