Modified secretin and method of synthesizing thereof

Details Modified secretin and method of synthesizing thereof Modified secretin and method of synthesizing thereof

C - Chemistry, Metallurgy

07

K

C07K 14/645 (2006.01) A61K 38/02 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 2/00 (2006.01)

Patent

CA 2505617

A secretin or derivative thereof being protected against peptidase activity. The secretin or derivative comprises a peptidic sequence; and a reactive group selected from the group consisting of succinimidyl and maleimido groups capable of reacting with an amino group, hydroxyl group or thiol group on a blood component to form a stable covalent bond. The reactive group is attached at a position along the peptidic sequence that provides, when conjugated to a blood component, a higher stability toward peptidase degradation than the unconjugated secretin or derivative, and maintenance of the therapeutic activity of the unconjugated secretin or derivative. Such a compound is thus effective to provide a source of secretine having a high stability toward peptidases. A method for synthesizing such a compound is also described.

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