Method for predicting the outcome of an infection

Details Method for predicting the outcome of an infection Method for predicting the outcome of an infection

G - Physics

01

N

G01N 33/48 (2006.01) G01N 33/68 (2006.01) G01N 33/84 (2006.01)

Patent

CA 2458667

A mathematical prognostic in which changes in a number of physiologically significant factors are measured and interpolated to determine a "damage function" incident to bacterial infection or other serious inflammation. By measuring a large number of physiologically significant factors including, but not limited to, Interleukin 6 (IL6), Interleukin 10 (IL10), Nitric Oxide (NO), and others, it is possible to predict life versus death by the damage function, dD/dt, which measures and interpolates differential data for a plurality of factors. In mammals, an IL6/NO ratio < 8 at 12 hours post infection is highly predictive (60%) of mortality; also in mammals, an IL6/NO ratio < 4 at 24 hours post infection is highly predictive (52%) of mortality; and an IL6/IL10 ratio in mammals of < 7.5 at 24 hours post infection is highly predictive (68%) of mortality.

La présente invention concerne un pronostic mathématique dans lequel des changements au niveau d'un certain nombre de facteurs physiologiquement significatifs sont mesurés et interpolés pour déterminer une </= fonction de dommage >/= incidente sur une infection bactérienne ou sur une autre inflammation grave. Par mesure d'un grand nombre de facteurs physiologiquement significatifs tels que, entre autres, l'interleukine 6 (IL6), l'interleukine 10 (IL10), l'oxyde nitrique (NO), et autres, on peut prédire la vie contre la mort au moyen de la fonction de dommage, dD/dt, qui mesure et interpole des données de différence pour une pluralité de facteurs. Chez les mammifères, un rapport IL6/NO inférieur à 8 à 12 heures après infection permet de prédire efficacement (60%) la mortalité; également chez les mammifères, un rapport IL6/NO inférieur à 4 à 24 heures après infection permet de prédire efficacement (52%) la mortalité; et un rapport IL6/IL10 chez les mammifères inférieur à 7,5 à 24 heures après infection permet de prédire efficacement (68%) la mortalité.

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