Use of picropodophyllin derivatives for treatment of igf-1r...

Details Use of picropodophyllin derivatives for treatment of igf-1r... Use of picropodophyllin derivatives for treatment of igf-1r...

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61P 5/06 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2451047

The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9' have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, such as cancer, psoriasis, artherosclerosis and acromegaly. A preferred compound is picropodophyllin.

L'invention concerne l'utilisation de cyclolignans spécifiques, dans lesquels les atomes de carbone en positions 9 et 9' présentent une configuration cis, dans l'inhibition du récepteur du facteur 1 de croissance de type insuline. Lesdits composés peuvent être utilisés pour le traitement de maladies dépendantes de IGF-1R, telles que le cancer, le psoriasis, l'artériosclérose et l'acromégalie. Un composé préféré est une picropodophylline.

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