Induction of rev and tat specific cytotoxic t-cells for...

Details Induction of rev and tat specific cytotoxic t-cells for... Induction of rev and tat specific cytotoxic t-cells for...

A - Human Necessities

61

K

A61K 39/21 (2006.01) A61K 31/70 (2006.01) C07K 14/16 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2268720

The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favourable prognosis of lack of progression to disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T- cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by stimulating, in the host, a specific cytotoxic T- cell response specific for the respective Rev and/or Tat proteins.

La présence de lymphocytes T cytotoxiques contre la protéine Rev et/ou Tat dans des échantillons prélevés sur un sujet infecté par le virus de l'immunodéficience, en particulier le VIH chez l'homme, et une indication d'un état pathologique stable et d'un pronostic favorable du manque de progression de la maladie. Des compositions immunogènes, contenant au moins un épitope de lymphocytes T cytotoxiques de la protéine Rev et/ou Tat d'un virus d'immunodéficience, en particulier le VIH, ou un vecteur codant cet épitope de lymphocytes T, peuvent être utilisées pour prévenir les infections par le virus de l'immunodéficience, en stimulant dans l'organisme hôte une réponse des lymphocytes T cytotoxiques qui soit spécifique des protéines Rev et/ou Tat correspondantes.

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