Dextran formulations and method for treatment of...

A - Human Necessities – 61 – K

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A61K 31/721 (2006.01) A61K 31/715 (2006.01) A61P 19/02 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2326510

This disclosure describes pharmaceutical compositions and a method for treatment of joint inflammation and pain brought about by e.g. arthritis, physical trauma, bacterial or viral infection. In one embodiment, the method comprises administration of a bimodal molecular weight dextran formulation comprising 0.2 to 32 % w/v of a dextran fraction with average molecular weight between 30,000 and 110,000 daltons and 0.2 to 6 % dextran with an average molecular weight between 500 and 3,000 daltons, into the joint of a warm blooded animal.

L'invention concerne des compositions pharmaceutiques et un procédé servant à traiter l'inflammation et la douleur articulaires provoquées, par exemple, par l'arthrite, un traumatisme physique ou une infection bactérienne ou virale. Dans un mode de réalisation, ce procédé consiste à administrer à l'intérieur de l'articulation d'un animal à sang chaud, une formulation de dextrane de poids moléculaire bimodal, à savoir qu'elle contient 0,2 à 32 % en poids et en volume d'une fraction de dextrane dont le poids moléculaire moyen est situé entre 30.000 et 110.000 daltons, et 0,2 à 6 % d'une fraction de dextrane dont le poids moléculaire moyen est situé entre 500 et 3.000 daltons.

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